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methylprednisolone will reduce the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.Lonafarnib may possibly raise the AUC and peak focus of CYP2C19 substrates. If coadministration unavoidable, check for adverse reactions and reduce the CYP2C19 substrate dose in accordance with its accepted pro